Check the Autodesk Knowledge Network for "Inventor 2021.2.2 Hotfix" — there may be post-2.2 patches that don't change the major version number but are essential for stability.
After applying both updates, check:
Significant updates to iLogic and sheet formats, allowing for faster, rules-based creation of 2D documentation. Download- Autodesk Inventor Pro 2021.2.2 build-...