While VS 2010 didn't have an official portable mode, its successors moved closer to that dream: Visual Studio Code : Unlike the full IDE, VS Code supports a true Portable Mode
On your USB drive, create a folder: E:\PortableVS\bin\ portable visual studio 2010 ultimate
rem Launch IDE start "" "%VSROOT%\Common7\IDE\devenv.exe" /nosplash While VS 2010 didn't have an official portable