Please ensure you have a compatible system and emulator (if required) to run the ISO version of the game.
By 2012, the hunt had moved to emulation. Xenia, the Xbox 360 emulator, could barely run 2D games. Rise of a Ninja would crash at the title screen. Someone on GBAtemp posted a modified ISO that replaced the region check with a NOP instruction (a null operation). It worked — but only on dev-kit firmware. Naruto Rise of a Ninja -Region libre--ISO-